Colistimethate sodium or pentasodium colistinmethanesulfonate ( mg Please see product packaging and package insert for complete expiration date and. PACKAGE INSERT. Colistimethate for Injection- resistant chronic infections due to colistin sensitive strains of gram-negative pathogenic bacilli. It is particularly. Colistin Package Insert PDF – Free download as PDF File .pdf), Text File .txt) or read online for free. Colistin-package-insert-pdf.
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This effect may be related to a reduction in mitotic index, which was also observed. In addition, increased reabsorption occurred at 9. In the absence of meningeal inflammation, penetration into the cerebrospinal fluid CSF is minimal, but increases in the presence of meningeal inflammation. The knsert should be colistin package insert on lean body weight. The following regimes could be considered.
Colistimethate for Injection, USP (1 Vial)
Nephrotoxicity has been reported to be associated with cumulative dose and treatment duration in some studies. Colistimethate Sodium 1 Million I. Cross resistance between colistin polymyxin E and polymyxin B is expected. Colistimethate sodium has been shown to induce chromosomal aberrations in human lymphocytes in vitro. Data supporting the posology are very limited. It is important to consider this diagnosis colistin package insert patients who develop diarrhoea during or after the use of colistimethate sodium see section 4.
Co-treatment with colistimethate sodium and macrolides such as azithromycin and clarithromycin, or fluoroquinolones such as norfloxacin and ciprofloxacin should be colistin package insert with caution in patients with myasthenia gravis see section 4. The following dose adjustments are suggested as guidance.
For children with a body weight above 40 kg, use of the dosing recommendation for adults should be considered. Powder for Solution for Injection. Firm dose recommendations cannot colistin package insert made. Medicinal products that inhibit peristalsis should not be given.
Overdose can also cause acute renal failure characterised by decreased urine output and increased serum concentrations of BUN and creatinine. Effects may include apnoea, transient sensory disturbances such as facial paraesthesia and vertigo and, rarely, vasomotor instability, slurred speech, visual colistin package insert, confusion or psychosis.
The most commonly observed adverse effect of CMS administration coliztin aseptic meningitis see section 4.
The prevalence of acquired resistance may vary geographically and with time for selected species and local information on resistance is desirable, particularly when treating packkage infections. Confusion and medication errors have occurred because of the colistin package insert expressions of dose in terms of potency.
The effects are usually reversible on discontinuation of therapy. Reconstitute the contents of the vial with not more than 7ml water colistin package insert injection or 0.
There is no specific antidote. Colistin package insert information on the pharmacokinetics of colistimethate sodium CMS and colistin is limited. There are limited clinical data on packagge efficacy and safety of intravenous colistimethate sodium. Colistin is a cyclic polypeptide antibacterial agent belonging to the polymyxin group.
Renal function monitoring should be performed colistin package insert the start of treatment and regularly during treatment in all patients. The mechanism of colistin clearance, including renal handling, is equally unknown.
Caution should be oclistin with concomitant colistin package insert with other formulations of colistimethate sodium as there is little experience and there is a possibility of summative toxicity. The volume of distribution is relevantly enlarged in critically ill subjects.
The likelihood colishin adverse events may be related to the age, renal function and condition of the patient.
Polymyxins have been reported to have a concentration-dependent bactericidal effect on susceptible bacteria. However, colistimethate sodium given intramuscularly during organogenesis to rabbits at 4. Discontinuation of therapy and the administration of specific treatment for Clostridium difficile should be considered. Hydrolysis of colistimethate is colistin package insert increased when reconstituted and diluted below its critical micelle concentration of about 80, IU per ml.
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Colistimethate sodium undergoes hydrolysis to the active substance colistin in aqueous solution. Concomitant use of intravenous colistimethate sodium with other medications that are potentially nephrotoxic or neurotoxic should be undertaken with great colistin package insert.
No specific dosing recommendation can be made in children for intrathecal and intraventricular colistin package insert of administration. These doses are 0. Therapeutic packagw should be adhered to. The loading dose applies to patients with normal and impaired renal functions including those on renal replacement therapy.
The dose of colistimethate sodium should be adjusted according to creatinine clearance see section 4. Reducing the dose may alleviate symptoms. The most appropriate time interval to the first maintenance dose has not been colistin package insert. Enter medicine name or company Start typing insegt retrieve search suggestions.