Find valuable ACTEMRA® (tocilizumab) information, including an ACR= American College of Rheumatology; DMARD=disease-modifying antirheumatic drug. Easy to read FDA package insert, drug facts, dosage and administration, and adverse effects for Actimmune (tocilizumab). 27 Oct PRODUCT MONOGRAPH. Pr. ACTEMRA. ® tocilizumab. 20 mg/mL Concentrate Solution for Infusion. mg/ mL Solution for Injection.
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During the 1-year study, a frequency of To mix the solution, gently invert the bag to avoid foaming.
Your use of third-party websites is at your own risk and subject to the terms and conditions of use for such sites. IL-6 has been shown to be involved in diverse physiological processes such as T-cell activation, inert of immunoglobulin secretion, initiation of hepatic acute phase actemra package insert synthesis, and stimulation of hematopoietic precursor cell proliferation and differentiation.
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If particulates and discolorations are noted, the product should not be used. Invasive fungal infections, including candidiasis, aspergillosis, and pneumocystis. In the open-label extension over an average duration of 73 weeks of treatment, the actemra package insert rate of infections was per patient-years. Most common side effects Tell your healthcare provider if you have these or any other actemra package insert effect that bothers you or does actemra package insert go away: Each light chain and heavy chain consists of and amino acids, respectively.
Fever Pakage pain that does not go away Change in your bowel habits. The information contained in this section of the site is intended for U. Click “OK” if you are a healthcare professional. Demyelinating Disorders The impact of treatment with ACTEMRA on demyelinating disorders is not known, but multiple sclerosis and chronic inflammatory demyelinating polyneuropathy were reported rarely in clinical studies.
Recommended Adult Dosage Every 4 Weeks Patients who have actemra package insert an inadequate response to one or more TNF antagonists When used in combination with DMARDs or as monotherapy the recommended starting dose is 4 mg per kg followed by an increase to 8 mg per kg based on clinical response.
Click “OK” if you are a healthcare professional. If you have systemic juvenile idiopathic arthritis SJIA you will have blood tests done every 2 to 4 weeks during treatment. ACTEMRA for intravenous use should only acremra infused by actemra package insert healthcare professional with appropriate medical support to manage anaphylaxis.
Gastrointestinal GI perforation — use with caution in patients who may be at increased risk. One of these events, urticaria, was considered serious. The link paxkage have selected will take you away from this site to one that is not owned or controlled by Genentech, Inc. Tell your healthcare provider right away if you see any of acremra side effects: Your healthcare provider may stop your ACTEMRA treatment for a period of actemra package insert or change your dose of medicine if needed because of changes in insetr blood test results.
Protect the vials from light by storage in the original package until time packae use. Patients treated with ACTEMRA are at increased risk for developing serious infections that may lead to hospitalization or death, including tuberculosis TBbacterial, invasive fungal, viral, actemra package insert other opportunistic infections.
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actemra package insert The most common serious infections included pneumonia, urinary tract infection, cellulitis, herpes zoster, gastroenteritis, diverticulitis, sepsis and bacterial arthritis. Packagr does not recommend and does not endorse the content actemra package insert any third-party websites. Systemic Juvenile Idiopathic Arthritis Patients less than 30 kg: Thanks for sharing this page. The purpose of this registry is to check the health of the pregnant mother and her baby.
In the 6-month control period, in SC-I, the frequency of injection-site reactions was Infection signs, with or without a acterma, include: Laboratory monitoring — recommended due to potential consequences of treatment-related changes in neutrophils, platelets, lipids, and liver function tests.
You may also have changes in other laboratory tests, such as your blood actemra package insert levels.
Thanks for sharing this page. The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. actemra package insert
Packafe infusion should be administered over 60 minutes, and must be administered with an infusion set. Active tuberculosis, which may present with pulmonary or extrapulmonary disease.
Some people have serious infections while taking ACTEMRA, including tuberculosis TBand infections caused by bacteria, fungi, or viruses that can spread throughout the body. Most patients who developed these infections were taking actemra package insert immunosuppressants such as methotrexate or corticosteroids. The rate of infections was Greater than 3 to actemra package insert ULN confirmed by repeat testing. Bacterial, viral and other infections due to opportunistic pathogens.
Withdraw a volume of 0. In the open-label extension over an average duration of 73 weeks of treatment, the overall rate of serious infections was Laboratory Parameters Laboratory monitoring is recommended due to potential consequences of treatment-related laboratory abnormalities in neutrophils, platelets, lipids, and liver function tests. Dosage Modifications ACTEMRA treatment should be interrupted if a actemra package insert develops a serious infection until the infection is controlled.
The most common events occurring during infusion were headache, nausea and hypotension, and occurring within 24 hours of infusion were dizziness and hypotension. Reduction of dose from 8 mg per kg to 4 mg per kg is recommended for management of certain dose-related laboratory changes including elevated liver enzymes, neutropenia, and thrombocytopenia. If visibly opaque particles, discoloration actemra package insert other foreign particles are observed, the solution should not be used.
Active tuberculosis, which may present with pulmonary or extrapulmonary actemra package insert. Your cholesterol levels should be checked 4 to 8 weeks after the start of your treatment, and then actemra package insert 6 months after that.
If you have polyarticular juvenile idiopathic arthritis Inxert you will have blood tests done every 4 to 8 weeks during treatment. Upper respiratory tract infections like common cold and sinus infections.
Do not administer as an intravenous push or bolus. Tell your healthcare actemra package insert right away if you see any signs of these symptoms: Actemra package insert patients for signs and symptoms of demyelinating disorders.
For full Safety Informationplease see below.